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Other - Cost: £652,109,405.62 Empagliflozin (Jardiance) - Cost: £7,788,101.39 Edoxaban (Lixiana) - Cost: £8,056,980.75 Influenza vaccine (Fluad) - Cost: £13,930,057.90 Beclometasone / Formoterol MDI (Fostair) - Cost: £17,160,087.08 Rivaroxaban (Xarelto) - Cost: £20,491,468.20 Apixaban (Eliquis) - Cost: £33,811,997.20
Formulary Notes (BNF Sub Paragraph)
NICE Guidance (4)
Other Links (11)
Important Local Documents (0)
Notes for: Other Immunomodulating Drugs
Last edited [27/06/2012 10:08:59]

With interferon the patient may experience symptoms of a flu-like illness and headaches, more common with the start of treatment and reduce with continued use. Dizziness, pins and needles, trembling, numbness, sleep disturbances, anxiety states, forgetfulness, drowsiness, confusion, depression, and suicidal behaviour have occurred.

 

Last edited [27/06/2012 10:48:04]
Last edited [27/06/2012 10:55:20]

Interferon Alfa

NICE guidance Peginterferon alfa, interferon alfa and ribavirin for chronic hepatitis C

TA106 'Hepatitis C - peginterferon alfa and ribavirin peginterferon alfa and ribavirin'

TA200 'Hepatitis C - peginterferon alfa and ribavirin peginterferon alfa and ribavirin'

TA75 'Interferon alfa (pegylated and nonpegylated) and ribavirin for the treatment of chronic hepatitis C'

 

Last edited [08/02/2013 14:44:37]

Interferon Beta

NICE guidance (interferon and glatiramer for multiple sclerosis) (January 2002) does not recommend either interferon beta or glatiramer acetate for the treatment of multiple sclerosis in the NHS in England and Wales.

NICE guidance (No. 127) Natalizumab for multiple sclerosis (August 2007) recommends that natalizumab is recommended as a possible treatment for people with rapidly evolving severe relapsing-remitting multiple sclerosis. NICE guidance on fingolimod in relapsing remitting multiple sclerosis (TAG 254, April 2012)

MHRA Drug Safety Update (May 2012) Fingolimod is not recommended in patient groups at high risk of cardiovascular adverse events, such as those with significant QT prolongation or history of bradycardia, ischaemic heart disease, cardiac failure, cerebrovascular disease, uncontrolled hypertension, and those receiving antiarrhythmic or heart-rate lowering drugs. Monitoring advice after the first dose has been updated.

MHRA Drug Safety Update (Jan 2013) Cardiovascular monitoring requirements for Fingolimod if treatment is interrupted and restarted. 

MHRA Drug Safety Update (Mar 2010) advises The risk of developing progressive multifocal leukoencephalopathy (PML) with natalizumab increases after 2 years of therapy. Patients with multiple sclerosis should be informed of the risk before treatment, and again after 2 years. The risk of developing PML beyond 3 years of treatment is currently unknown.

 

Cornwall Joint Formulary Recommended Choices     (...Top)
Displaying 23 Drugs

Key:
First Line Drugs First Line Drugs
Second Line Drugs Second Line Drugs
Specialist Initiated Drugs Specialist Initiated Drugs
Hospital Only Drugs Hospital Only Drugs
Discouraged Discouraged
No comment available No comment available
Antibiotics Antibiotics

NameTariffBNF Sub Paragraph
Glatiramer acetate
20 mg / 1 mL injection Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Glatiramer acetate'View SPC on 'Glatiramer acetate'View PIL on 'Glatiramer acetate'
Interferon alfa-2a (Roferon-A)
6 million unit prefilled syringe Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2a (Roferon-A)'View SPC on 'Interferon alfa-2a (Roferon-A)'View PIL on 'Interferon alfa-2a (Roferon-A)'
Interferon alfa-2a (Roferon-A)
9 million unit prefilled syringe Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2a (Roferon-A)'View SPC on 'Interferon alfa-2a (Roferon-A)'View PIL on 'Interferon alfa-2a (Roferon-A)'
Interferon alfa-2a (Roferon-A)
18 million unit prefilled syringe Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2a (Roferon-A)'View SPC on 'Interferon alfa-2a (Roferon-A)'View PIL on 'Interferon alfa-2a (Roferon-A)'
Interferon alfa-2b (Intron-A)
15 million units / mL, 1.5 mL cartridge Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2b (Intron-A)'View SPC on 'Interferon alfa-2b (Intron-A)'View PIL on 'Interferon alfa-2b (Intron-A)'
Interferon alfa-2b (Intron-A)
25 million units / mL, 1.5 mL cartridge Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2b (Intron-A)'View SPC on 'Interferon alfa-2b (Intron-A)'View PIL on 'Interferon alfa-2b (Intron-A)'
Interferon alfa-2b (Intron-A)
50 million units / mL, 1.5 mL cartridge Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2b (Intron-A)'View SPC on 'Interferon alfa-2b (Intron-A)'View PIL on 'Interferon alfa-2b (Intron-A)'
Interferon beta - 1a (Rebif®)
22 micrograms prefilled syringe (6 million units) Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon beta - 1a'View SPC on 'Interferon beta - 1a'View PIL on 'Interferon beta - 1a'
Interferon beta - 1a (Avonex®)
30 micrograms prefilled syringe (6million units) Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon beta - 1a'View SPC on 'Interferon beta - 1a'View PIL on 'Interferon beta - 1a'
Interferon beta - 1a (Rebif®)
44 micrograms prefilled syringe (12 million units) Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon beta - 1a'View SPC on 'Interferon beta - 1a'View PIL on 'Interferon beta - 1a'
Interferon beta - 1b (Betaferon®)
300 micrograms vial injection (9.6 million units) Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon beta - 1b'View SPC on 'Interferon beta - 1b'View PIL on 'Interferon beta - 1b'
Natilizumab
20 mg / 1 mL concentrate for i/v infusion Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Natilizumab'View SPC on 'Natilizumab'View PIL on 'Natilizumab'
Peginterferon alfa - 2a (Pegasys®)
180 microgram prefilled syringe Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Peginterferon alfa - 2a (Pegasys®)'View SPC on 'Peginterferon alfa - 2a (Pegasys®)'View PIL on 'Peginterferon alfa - 2a (Pegasys®)'
Interferon alfa-2a (Roferon-A)
3 million unit prefilled syringe Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2a'View SPC on 'Interferon alfa-2a'View PIL on 'Interferon alfa-2a'
Interferon alfa-2b (Intron-A)
10 million units vial powder for reconstitution Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2b (Intron-A)'View SPC on 'Interferon alfa-2b (Intron-A)'View PIL on 'Interferon alfa-2b (Intron-A)'
Interferon alfa-2a (Roferon-A)
18 million unit Cartridge Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Interferon alfa-2a'View SPC on 'Interferon alfa-2a'View PIL on 'Interferon alfa-2a'
Peginterferon alfa - 2a (Pegasys®)
135 microgram prefilled syringe Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Peginterferon alfa - 2a (Pegasys®)'View SPC on 'Peginterferon alfa - 2a (Pegasys®)'View PIL on 'Peginterferon alfa - 2a (Pegasys®)'
Bacillus Calmette-Guérin (ImmuCyst®)
81 mg vial Bladder Instillation Pack of 1
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Bacillus Calmette-Guérin'View SPC on 'Bacillus Calmette-Guérin'View PIL on 'Bacillus Calmette-Guérin'
DIMETHYL FUMARATE (Tecfidera)
120 mg Capsules Pack of 14
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'DIMETHYL FUMARATE'View SPC on 'DIMETHYL FUMARATE'View PIL on 'DIMETHYL FUMARATE'
Fingolimod (Gilenya)
500 microgram capsules Pack of 7
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Fingolimod'View SPC on 'Fingolimod'View PIL on 'Fingolimod'
Glatiramer Acetate Injection (Copaxone Injection)
20 mg / 1ml prefilled syringe Pack of 28
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Glatiramer Acetate Injection'View SPC on 'Glatiramer Acetate Injection'View PIL on 'Glatiramer Acetate Injection'
Teriflunomide (Aubagio)
14 mg Tablet Pack of 28
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Teriflunomide'View SPC on 'Teriflunomide'View PIL on 'Teriflunomide'
Fingolimod (Gilenya)
500 microgram capsules Pack of 28
- PCT FORMULARY STATUS: Hospital Only Drugs Other Immunomodulating DrugsView BNF Article on 'Fingolimod'View SPC on 'Fingolimod'View PIL on 'Fingolimod'

 
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